Our Expertise in Synthetic Chemistry

Accelerating drug discovery with high-quality compounds and flexible business models.

Synthetic Chemistry

Alentris Synthesis offers a broad spectrum of synthetic chemistry services aimed at accelerating the drug discovery process for biotech and pharmaceutical innovators worldwide. With a team of skilled scientists proficient in tackling complex synthetic routes, we specialize in synthesizing high-quality compounds with rapid speed. We work on early-stage discovery projects, producing intermediates, building blocks, and final compounds from milligrams to multi-kilograms.

We provide flexible business arrangements including Fee for Service (FFS), Time & Material, or Full-Time Equivalent (FTE) options to best suit the needs of our clients.

Our expertise in synthetic chemistry

Traditional Heterocyclic Chemistry

Synthesis of O, N, S, and P heterocyclic compounds and fused-ring analogues, such as Benzofuran, Azaindole, Thiophene, and Thiazole formations.

Transition Metal-Mediated Reactions

Expertise in reactions like Suzuki Coupling, Negishi & Heck Coupling, Buchwald-Hartwig Coupling, Phosphonate Chemistry, C-P, C-S, C-B, C-Sn, and C-Si bond-forming reactions, and C-H activation.

Difficult Handle & Sensitive Reagents

Including all kinds of metal-based pyrophoric reagents like lithium, magnesium and zincs, toxic reagents like metallic cyanides and metal carbonyls e.g., Reduction, Catalytic hydrogenation, Grignard, Hydroxymethylation etc.

Handling of Gaseous Reagents

Experience in reactions involving gases such as H2, Cl2, O2, CO, CO2, and SO3, as well as rarer reactions like ozonolysis. Applications include Chloromethylation, Bromination, and Halogenation.

High-Temperature Reactions

Capable of performing high-temperature reactions up to 290°C, ensuring efficiency in complex synthetic processes.

Nitration, Reduction, and Migration

Expertise in nitration, reduction, and migration reactions under various conditions.

Special Synthetic Reactions

Experience in cryogenic reactions, pyrophoric reagents, fluorinations, synthesis of fluoroalkyl and fluoroalkoxy targets, cyclopropanations, deuterations, isotope synthesis, and more.

Our chemical synthesis capabilities

1
Library and Analog Synthesis: Experience in synthesizing a range of libraries, from focused libraries of 10-100 members to complex multi-step scaffold synthesis.
2
Catalyst Screening: Expertise in the synthesis and screening of various catalysts, including Iridium and Vanadium complexes.
3
Nucleotides: Ability to synthesize a variety of nucleotides and
nucleosides.
4
Protein Degraders (PROTACs): Proficiency in the synthesis of heterobifunctional target molecules for protein degradation.
5
Asymmetric Synthesis/Chiral Pool Synthesis: Experience in asymmetric reactions such as aldol, Diels-Alder, transfer hydrogenation, reductions, dihydroxylation, and hydrosilylation, as well as racemic mixture resolution.
6
Carbohydrates: Skilled in the synthesis of a wide range of carbohydrate-based compounds.
7
Chiral Separation: Capability to separate chirally pure compounds via crystallization, resolution, and prep HPLC purification.
8
Metabolites: Experts in the synthesis of metabolites for research & development.

Other Services

Custom Synthesis Services

At Alentris Synthesis, we offer end-to-end custom synthesis solutions under a "Fee for Service" (FFS) business model, leveraging advanced scientific expertise and infrastructure. Our team specializes in synthesizing complex molecules, tackling even the most challenging chemistry with innovative approaches tailored to client needs.

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Discovery Chemistry

At Alentris Synthesis, we lead the way in drug discovery chemistry services, leveraging the exceptional expertise of our scientists and state-of-the-art infrastructure. Our team of drug discovery chemists possesses extensive experience, particularly in multi-step organic synthesis across diverse therapeutic

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Medicinal Chemistry

At Alentris Synthesis, our medicinal chemistry contract research services feature a dedicated team of scientists collaborating with industry leaders and computational chemistry experts. We cater to mg-to-kg scale chemistry requirements, offering innovative and efficient solutions.

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Library Synthesis

At Alentris Synthesis, we specialize in designing, executing, and delivering compound libraries tailored to client needs. Our in-house technical expertise enables the efficient creation of both general and focused libraries, ensuring high-quality results. We consistently achieve over 70% compound delivery success rates and greater than 90% compound purity.

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