Our Expertise in Discovery Chemistry
Pioneering innovative solutions for drug discovery and development.
Discovery Chemistry
At Alentris Synthesis, we lead the way in drug discovery chemistry services, leveraging the exceptional expertise of our scientists and state-of-the-art infrastructure. Our team of drug discovery chemists possesses extensive experience, particularly in multi-step organic synthesis across diverse therapeutic domains. Their contributions are integral to our comprehensive and synergistic discovery programs, driving innovative and effective solutions for our clients.
- We provide route design and synthesis support for “Novel Chemistry Targets” under CDA and MSA agreements. Our approach focuses on creating libraries and diverse scaffolds of desired skeletons to support New Chemical Entities (NCEs).
- We specialize in the synthesis of multi-step complex molecules at milligram to gram scales, enabling clients to quickly evaluate metabolic stability and the bioactivity of lead compounds.
- The targets under our Full-Time Equivalent (FTE) services are produced swiftly to support clients’ NCE (New Chemical Entity) and NDDS (Novel Drug Delivery System) projects.
- We support the synthesis of challenging and rare-to-make chemistry molecules under this category of service.
- We deliver chemistry targets with exceptional speed, ensuring >95% purity by LCMS and clean, accurate HNMR data.
Hit to Lead
At Alentris Synthesis, our seasoned scientists leverage years of expertise in drug discovery to transform hits into high-potency leads, accelerating their progression to the lead optimization phase. Our meticulous evaluation process examines hits for critical factors such as potency, selectivity, and drug-likeness, ensuring that only the most promising compounds move forward.
With our extensive drug discovery experience, we excel in designing analogs with enhanced drug-likeness, adding significant value to each program.
Route Scouting and Focused Library Synthesis
Our expertise includes route scouting and the synthesis of focused libraries, providing a versatile toolkit to explore and generate compounds of interest efficiently and effectively.
Lead Optimization
Using identified lead compounds from the hit-to-lead stage, our scientists optimize and evaluate leads through comprehensive screening studies, preparing them for preclinical development. This process ensures high-quality candidates for drug development.
Design of Hypothesis
Multi-Parameter Optimization
Optimization Studies
Early Scale-Up
Preclinical Candidate Selection
Other Service
Custom Synthesis Services
At Alentris Synthesis, we offer end-to-end custom synthesis solutions under a "Fee for Service" (FFS) business model, leveraging advanced scientific expertise and infrastructure. Our team specializes in synthesizing complex molecules, tackling even the most challenging chemistry with innovative approaches tailored to client needs.
Library Synthesis
At Alentris Synthesis, we specialize in designing, executing, and delivering compound libraries tailored to client needs. Our in-house technical expertise enables the efficient creation of both general and focused libraries, ensuring high-quality results. We consistently achieve over 70% compound delivery success rates and greater than 90% compound purity.
Synthetic Chemistry
Alentris Synthesis offers a broad spectrum of synthetic chemistry services aimed at accelerating the drug discovery process for biotech and pharmaceutical innovators worldwide. With a team of skilled scientists proficient in tackling complex synthetic routes, we specialize in synthesizing high-quality compounds with rapid speed. We work on early-stage discovery projects, producing intermediates, building blocks, and final compounds from milligrams to multi-kilograms.
Medicinal Chemistry
At Alentris Synthesis, our medicinal chemistry contract research services feature a dedicated team of scientists collaborating with industry leaders and computational chemistry experts. We cater to mg-to-kg scale chemistry requirements, offering innovative and efficient solutions.